Skip to product information
1 of 1

DermaFit

Retinoid Trifecta Serum

Retinoid Trifecta Serum

Regular price R 1,860.00 ZAR
Regular price Sale price R 1,860.00 ZAR
Sale Sold out

Triple-Action Bioactive Retinoid Serum 

Resurface. Regenerate. Refine.

Retinoid Trifecta is an advanced, prescription-strength performance serum powered by a synergistic blend of three clinical-grade retinoids. Designed to tackle dullness, fine lines, uneven texture, and pigmentation, this night-time formula delivers multi-depth cellular renewal with minimal irritation.

Combining Hydroxypinacolone Retinoate (HPR), Retinol, and Retinyl Palmitate, this intelligent formula boosts collagen, improves skin clarity, and smooths the signs of photoageing, all supported by a dermal delivery system for maximum results and stability.


Key Benefits

  • Boosts skin renewal & smooths texture
  • Reduces fine lines, wrinkles & signs of ageing
  • Targets uneven tone & sun-induced pigmentation
  • Supports collagen regeneration
  • Delivers prescription-level results with enhanced tolerability

Hero Ingredients

  • Hydroxypinacolone Retinoate (HPR) – a direct-acting retinoid with minimal irritation
  • Retinol & Retinyl Palmitate – improve tone, texture & firmness
  • Squalane & Jojoba Oil – hydrate, calm & support barrier recovery
  • Vitamin E – protects against oxidative damage

How to Use

Apply to clean, dry skin at night, 2–3 times per week. Increase frequency as tolerated. Always follow with a moisturizer and apply SPF daily. Do not combine with other retinoids or exfoliating acids in the same routine. Avoid broken or irritated skin.

Pro Tip: Use consistently as part of your nighttime routine. Start slow and build up for long-term, visible transformation.


Skin Type: All skin types (not recommended for use during pregnancy)
Size: 30ml
Made in South Africa

Why Retinoid Trifecta is Different

Most retinols convert multiple times in the skin before becoming active, which makes them less predictable and more irritating — especially in summer when skin is already exposed to heat and UV.

The Retinoid Trifecta combines three retinoids:

Hydroxypinacolone Retinoate (HPR) → a direct-acting, receptor-targeted retinoid that works without conversion. It delivers prescription-level results with much less irritation and sensitivity.

Retinol → time-tested, boosts cell turnover and collagen.

Retinyl Palmitate → gentler form that supports long-term skin renewal.

Why It’s Summer-Safe

Stability & Delivery System → Trifecta uses a specialised delivery system that protects the retinoids from breaking down in heat or light, releases them gradually, and enhances penetration while reducing irritation.

Reduced Sensitisation → The HPR base is far less photosensitising than pure retinol, making it safer to use consistently — even in warmer months.

Barrier Support → Formulated with squalane, jojoba oil, and Vitamin E, it nourishes while renewing, preventing the dryness and peeling often triggered by retinol use in summer.

Important Client Guidance

You can use Retinoid Trifecta nightly in summer, but SPF 50 every morning is non-negotiable.

Unlike older retinols that often require cycling or skipping in hotter seasons, Trifecta’s controlled release means your skin adapts smoothly without the rollercoaster of irritation.

It’s about consistency — keeping your skin on a steady renewal plan all year round instead of stopping retinol during summer and losing progress.

In short:
Retinoid Trifecta is designed to be high-strength but low-irritation. Thanks to its direct-acting HPR, stabilised blend, and advanced delivery system, it allows you to keep your skin transformation journey going every night even in summer, provided you’re diligent with daily SPF protection.

View full details

Customer Reviews

Be the first to write a review
0%
(0)
0%
(0)
0%
(0)
0%
(0)
0%
(0)